UTRF Research Tools, Materials, and Software
Toxoplasma gondii whole-cell antigen for modified agglutination test (MAT): Toxoplasma gondii is an obligate intracellular parasite that infects mammals and birds. A modified agglutination test (MAT) can be used to detect anti-Toxoplasma IgG antibodies in serum, plasma and other bodily fluid samples of animals. For MAT test, formalin-treated Toxoplasma tachyzoite is used as the antigen.
Liposome siRNA Encapsulation (LSE) is a liposome assembly technique to enhance siRNA cargo loading into PEGylated neutral liposomes for improved biocompatibility and pharmacokinetics. This results in liposomal nanocarriers with efficient nucleic acid encapsulation and enhanced cellular association, while minimizing the cytotoxic effects associated with cationic-mediated transfection. LSE is a quick, easy, reproducible, scalable method for nanoparticle-mediated applied transfection.
TELBOXX is a tamper-evident device that minimizes unauthorized access to a central line and shows unambiguous evidence of tampering. This easy-to-use device will potentially enable hospitals to safely discharge intravenous drug users for outpatient care or to a skilled nursing facility for follow-on care.
The automated bioinformatics analysis package using the system on a chip was created to offer researchers cheap, portable, streamlined analysis for RNA-Seq and Microarray Gene Expression. The package accepts SAM files as input, performs counts per million (CPM) normalization across the experiment, calculates standard deviation, standard error of means or variance within each sample group, calculates Student’s t-test between groups, provides false discovery rates using the Benjamini-Hochberg procedure, and heat maps, as well as Venn diagrams. These outputs are all performed on a Raspberry Pi System that is very portable and cost-effective.
A method developed for crafting synthetic nuclear melt glass for forensic analysis. A synthetic glass that can be used to simulate a variety of scenarios and will help develop and validate forensic analysis methods.
Process and Equipment Monitoring (PEM) Toolbox & the Process and Equipment Prognostics (PEP) Toolbox
The Process and Equipment Monitoring (PEM) Toolbox is a MATLAB based set of tools that provides a generalized set of functions for use in process and equipment monitoring applications, specifically on-line monitoring systems (OLM).
The Process and Equipment Prognostics (PEP) Toolbox is a set of MATLAB‐based tools that facilitate fast prototyping of empirical‐based prognostic models developed at the University of Tennessee Nuclear Engineering Department.
CRISPR Associated Software for Pathway Engineering and Research
(contact UTRF for more information)
This MATLAB-based software enhances CRISPR genetic engineering, allowing any genome to be edited by predictable identification of both on- and off-target sites and analysis of repeated targets. Novel applications include multi-site gRNA integration and gRNA design for genome editing across a consortium of organisms.
Design, view and share fetal heart rate and contraction charts and learn the basics of Electronic Fetal Monitoring (EFM) in a fun and intuitive way with the simulated app.